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Active CASP3 Monoclonal Antibody

Active CASP3 Monoclonal Antibody

Item no.	E-AB-22115-120
Manufacturer	Elabscience
Amount	120 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot Immunofluorescence Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies
Type	Antibody Monoclonal
Applications	WB, IF, IHC-P
Clone	5A2
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	https://www.sciencedirect.com/science/article/pii/S2162253122003006 https://www.mdpi.com/1806946 https://pubs.rsc.org/en/content/articlelanding/2021/fo/d1fo01547h https://www.sciencedirect.com/science/article/pii/S1382668920300880 https://www.sciencedirect.com/science/article/pii/S0161813X18304170 https://www.spandidos-publications.com/10.3892/ol.2018.9635?text=abstract https://link.springer.com/article/10.1134/S0022093021060120
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	A830040C14Rik, Apopain, CASP-3, CASP3, CASP3, Casp3a, Caspase 3, Caspase 3, apoptosis-related cysteine peptidase, Caspase 3, apoptosis-related cysteine protease, Caspase 3, apoptosis-related cysteine protease a, Caspase-3 subunit p12, CC3, CPP-32, CPP32, CPP32B, Cysteine protease CPP32, EC 3.4.22.56, LICE, mldy, OTTHUMP00000165052, OTTHUMP00000165053, OTTHUMP00000165054, PARP cleavage protease, Procaspase3, Protein Yama, SCA 1, SCA-1, SREBP cleavage activity 1, Yama
Similar products	CASP3, CPP32, Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, Caspase-3 subunit p12, CC3, LICE, CASP-3, CPP-32, SCA-1, Caspase 3, apoptosis-related cysteine protease, CPP32B, PARP cleavage protease, Yama, A830040C14Rik, mldy, SCA 1, OTTHUMP00000165054, Procaspase3, Casp3a, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease a, EC 3.4.22.56, OTTHUMP00000165052, OTTHUMP00000165053
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	Active Caspase-3
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Observed Molecular Weight	17kDa
Manufacturer - Research Areas	Cancer, Cell Biology, Metabolism, Neuroscience
Background	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Concentration	1 mg/mL
Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Purification Method	Protein A purification
Recommended Dilution	WB 1:500-1:1000; IHC 1:100-1:200; IF 1:100-1:200
Abbreviation	Active Caspase-3
Clonality	Monoclonal
Immunogen	Recombinant Protein
Category ID III	Monoclonal Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.