Vergleich

Recombinant Human EphB6 Protein

ArtNr ELS-PKSH031773-100ug
Hersteller Elabscience
Menge 100 ug
Quantity options 100 ug 200 ug
Kategorie
Typ Proteins
Format Lyophilized Powder
Applikationen ELISA
Specific against Human (Homo sapiens)
Host HEK293 cells
Konjugat/Tag Untagged
Purity > 95 % as determined by reducing SDS-PAGE.
Sequence Met 1-Ser 579
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias HEP
Similar products HEP
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Category
Recombinant Proteins / Others
Manufacturer - Conjugate / Tag
None
Shipping Temperature
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Calculated Molecular Weight
60.4 kDa
Observed Molecular Weight
72 kDa
Background
Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 is an unusual Eph receptor; lacking catalytic capacity due to alterations in its kinase domain. Interestingly; increased metastatic activity is associated with reduced EphB6 receptor expression in several tumor types; including breast cancer. This emphasizes the potential of EphB6 to act as a suppressor of cancer aggressiveness. EphB6 suppress cancer invasiveness through c-Cbl-dependent signaling; morphologic changes; and cell attachment and indicate that EphB6 may represent a useful prognostic marker and a promising target for therapeutic approaches. EphB6 can both positively and negatively regulate cell adhesion and migration; and suggest that tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition. In addition; Ephrin-B2 may be a physiological ligand for the EphB6 receptor.
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution
Please refer to the printed manual for detailed information.
Formulation
Lyophilized from sterile 100mM NaCl, 50mM Tris, pH 7.5
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Activity
Immobilized human EphB6 at 10 μg/mL (100 μl/well) can bind biotinylated human EFNB2-Fch with a linear range of 1. 56-50 ng/mL.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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