Mouse Gpr161 Antibody (1A8), mAb, Mouse

USA

The lyophilized product remains stable up to 1 year at -20 C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 C or for up to 12 months at -20 C or below. Avoid freeze/thaw cycles.

The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. It’s the key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. It is recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, which leads to PKA-dependent processing of GLI3 into GLI3R and represses the Shh signaling. In presence of SHH, it’s removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling.