Vergleich

TNF-α, Human Europäischer Partner

Hersteller GenScript
Kategorie
Typ Proteins
Specific against Human
Menge 1 mg
ArtNr Z01001-1
Targets PTPRC, FOXD3, CD241, LCN2, TNF, IL6
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Specificity
The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is less than 0.03ng/ml, corresponding to a Specific Activity of 3.0x107 IU/mg.
Description
Tumor Necrosis Factor-alpha (TNF-a), is a homotrimer with a subunit molecular mass of 17, 000 Da. Tumor Necrosis Factor-alpha (TNF-a) plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases, and in viral, bacterial, fungal, and parasitic infections. Besides inducing hemorrhagic necrosis of tumors, TNF has been found to be involved in tumorigenesis, tumor metastasis, viral replication, septic shock, fever, inflammation, and autoimmune diseases including Crohn's disease, and rheumatoid arthritis as well as graft-versus-host disease. Recombinant human tumor necrosis factor-alpha (TNF-a), is a non-glycosylated cytokine produced from, E. coli, using rDNA technology. The protein consists of three identical polypeptide chains of 158 amino acids combined to form a compact, bell-shaped homotrimer. The individual subunits have a relative molecular mass each of 17, 484 Da. TNF alpha-1a is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells.
Endotoxin Level
Less than 0.1 ng/ug (1 IEU/ug) determined by LAL test
Formulation
The protein was lyophilized after extensive dialysis against PBS, pH7.3.
M.W.
17, 300 Da+/-10% determined by reduced SDS-PAGE
Product Line
Cytokine, Chemokines & Growth Factors
Reconstitution
It is recommended that the lyophilized, recombinant human tumor necrosis factor alpha (TNF-alpha), be reconstituted in sterile 18 Momega-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Storage
Lyophilized samples are stable for up to 12 months from date of delivery if stored between -20C and -70C. Avoid repeated freeze-thaw cycles.
Manufacturers Category
Proteins
Manufacturers Product Line
Cytokines
Product Origin
USA

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 1 mg
Lieferbar: In stock
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Lieferung vsl. bis 18.04.2024 

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