TNF-α, Human

Tumor Necrosis Factor-alpha (TNF-a), is a homotrimer with a subunit molecular mass of 17, 000 Da. Tumor Necrosis Factor-alpha (TNF-a) plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases, and in viral, bacterial, fungal, and parasitic infections. Besides inducing hemorrhagic necrosis of tumors, TNF has been found to be involved in tumorigenesis, tumor metastasis, viral replication, septic shock, fever, inflammation, and autoimmune diseases including Crohn's disease, and rheumatoid arthritis as well as graft-versus-host disease. Recombinant human tumor necrosis factor-alpha (TNF-a), is a non-glycosylated cytokine produced from, E. coli, using rDNA technology. The protein consists of three identical polypeptide chains of 158 amino acids combined to form a compact, bell-shaped homotrimer. The individual subunits have a relative molecular mass each of 17, 484 Da. TNF alpha-1a is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells.

The protein was lyophilized after extensive dialysis against PBS, pH7.3.

Cytokine, Chemokines & Growth Factors

Lyophilized samples are stable for up to 12 months from date of delivery if stored between -20C and -70C. Avoid repeated freeze-thaw cycles.

Cytokines