Pegylated Interferon-alpha 2b, human

Although lyophilized PEG-IFN-alpha 2b remains stable at room temperature for three weeks, it is ideally stored desiccated below -18C. Upon reconstitution, PEG-IFN-alpha 2b may be stored at 4C for up to one week and below -18C for longer periods. For long-term storage it is recommended that a carrier protein (0.1% HSA or BSA) be added. Avoid freeze-thaw cycles.

Cytokine, Chemokines & Growth Factors

At least 23 different variants of Interferon-alpha are known. The individual proteins have molecular masses between 19, 000-26, 000 Da and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-alpha subtypes possess a common conserved sequence region between amino acid positions 115 and 151, but the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxyl-terminal end. Recombinant Human Interferon-alpha 2b produced in, E. coli, is a single, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 19, 269 Da. GenScript, Pegylated Interferon-alpha 2b, human, is manufactured by attaching a 40, 000 Da NHS-mPEG to the primary amino acid of IFN-alpha 2b.

Lyophilized from a (1 mg/ml) solution in containing 5.55 mg sodium phosphate dibasic, 5.55 mg sodium phosphate monobasic buffer, 296 mg sucrose and 0.37 mg Tween 80