Endostatin, Human

Hersteller GenScript
Kategorie
Typ Proteins
Specific against Human
Menge 100ug
ArtNr Z02533-100
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Product Line
Others
Description
Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
Purity
Greater than 97% by SDS-PAGE
Endotoxin Level
Endotoxin level is less than 0.1 ng per ug (1EU/ug) of Endostatin.
Specific Activity
Determined by Endothelial Cell Tube Formation. The cells treated with 10μ, g/ml Endostatin showed significant anti-angiogenesis effect.
Storage
The lyophilized Endostatin is stable for a few weeks at room temperature, but best stored at -20C. For the first use, reconstitute in water, aliquot and store at -20C to avoid multiple freeze-thaws.
Formulation
The sterile filtered solution was lyophilized with 17 mM citric-phosphate buffer, pH 6.2.

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Menge: 100ug
Lieferbar: In stock
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