Item no. |
Z02533-100 |
Manufacturer |
GenScript
|
Amount |
100 ug |
Category |
|
Type |
Proteins |
Specific against |
Human |
Purity |
Greater than 97% by SDS-PAGE |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
protein/Z02533-Endostatin, Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.</td></tr><tr><th>Purity</th><td colspan="7"> Greater than 97% by SDS-PAGE</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Endotoxin level is less than 0.1 ng per ug (1EU/ug) of Endostatin.</td></tr><tr><th>Specific Activity</th><td colspan="7"> Determined by Endothelial Cell Tube Formation. The cells treated with 10& |
Similar products |
Endostatin |
Available |
|
Specificity |
Determined by Endothelial Cell Tube Formation. The cells treated with 10μ,g/ml Endostatin showed significant anti-angiogenesis effect. |
Specificity |
Determined by Endothelial Cell Tube Formation. The cells treated with 10μ, g/ml Endostatin showed significant anti-angiogenesis effect. |
Description |
Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues. |
Endotoxin Level |
Endotoxin level is less than 0.1 ng per ug (1EU/ug) of Endostatin. |
Formulation |
The sterile filtered solution was lyophilized with 17 mM citric-phosphate buffer, pH 6.2. |
Product Line |
Others |
Storage |
The lyophilized Endostatin is stable for a few weeks at room temperature, but best stored at -20C. For the first use, reconstitute in water, aliquot and store at -20C to avoid multiple freeze-thaws. |
Manufacturers Category |
Proteins |
Manufacturers Product Line |
Other Proteins |
Product Origin |
USA |
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