IL-1β, Human

ArtNr	Z02922-1
Hersteller	GenScript
Menge	1 mg
Quantity options	1 mg 10 ug 50 ug
Kategorie	Neuroscience Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines Cytoskeleton Cell Stainings ECM Cardiovascular Research Hypertension Intermediate filaments
Typ	Proteins
Specific against	Human (Homo sapiens)
Purity	> 95% by SDS-PAGE and HPLC analyses.
Sequence	Ala117-Ser269 (accession number: P01584 ).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02922_1-Interleukin_1_beta_IL_1_Human,Interleukin-1 beta (rhIL-1beta), is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine. Recombinant, human Interleukin-1 beta (rhIL-1beta), produced in, E. coli, is a single non-glycosylated polypeptide chain containing 153 amino acids. A fully biologically active molecule, rhIL-1beta has a molecular mass of 17.3kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.</td></tr><tr><th>M.W.</th><td colspan="7"> 17.3 kDa, observed by reducing SDS-PAGE.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% by SDS-PAGE and HPLC analyses.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> <0.2 EU/ug, determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> ED50< 1.0 pg/ml, measured by the dose-dependent stimulation of mouse D10S cells, corresponding to a specific activity of 1.0× 109 IU/mg.</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant, human Interleukin-1 beta (rhIL-1beta), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhIL-1beta should be stable up to 2 weeks at 4C or up to 3 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized after extensive dialysis against PBS.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O or PBS at 100 ug/ml.</td></tr><tr><th>Sequence</th><td colspan="7"> Ala117-Ser269 (accession number: P01584 ).</td></tr>
Similar products	Interleukin-1
Versandbedingung	Gekühlt
Lieferbar
Specificity	ED50< 1.0 pg/ml, measured by the dose-dependent stimulation of mouse D10S cells, corresponding to a specific activity of 1.0x 109 IU/mg.
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	17.3 kDa, observed by reducing SDS-PAGE.
Product Line	Cytokines
Manufacturer - Specificity	ED50< 1.0 pg/ml, measured by the dose-dependent stimulation of mouse D10S cells, corresponding to a specific activity of 1.0x 109 IU/mg.
Description	Interleukin-1 beta (rhIL-1beta), is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine. Recombinant, human Interleukin-1 beta (rhIL-1beta), produced in, E. coli, is a single non-glycosylated polypeptide chain containing 153 amino acids. A fully biologically active molecule, rhIL-1beta has a molecular mass of 17.3kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Endotoxin Level	<0.2 EU/ug, determined by LAL method.

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