G-DNF, Human

ArtNr	Z02927-50
Hersteller	GenScript
Menge	50 ug
Quantity options	1 mg 10 ug 50 ug
Kategorie	Neuroscience Neuroinflammation Metabolism Diabetes Neural Mitochondrial Function Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Protein Aggregation, Clearance & Misfolding Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Autophagy Cardiovascular Research Hypertension
Typ	Proteins
Specific against	Human (Homo sapiens)
Purity	> 95% as analyzed by SDS-PAGE and HPLC.
Sequence	Ser78 – Ile211 (Accession # P39905)
Citations	1. Pascual, A. et al. (2011) J Mol Endocrinol 46: R83-R92Gauldie, J. et al. (1987) Proc. Natl. Acad. Sci. USA, 84, 7251-7255. 2. Roussa E. et al. (2009) Adv Exp Med Biol. 651:81-90. 3. Hong M. et al. (2008) Expert Rev Neurother. 8:1125-39. 4. Gordon, T. (2009) Neurosurg Focus. 26:E3. 5. Jing, S. et al. (1997). J. Biol. Chem. 272 (52): 33111–7, 6. Cik, M. et al. (2000). J. Biol. Chem. 275: 27505–12, 7. Takahashi, M. et al. (2001). Cytokine Growth Factor Rev. 12:361-73.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02927_50-G_DNF_Human,Glial cell line-derived neurotrophic factor (G-DNF), is a neurotrophic factors belong to TGF-beta super family necessary for neuron survival and phenotypic maintenance in central and peripheral nervous systems [1]. G-DNF, has the potent to support the differentiation and survival of many neuron subpopulations, prominent for dopaminergic neurons [2] and motor neurons [3], as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human [4]. GDNF has shown to interact with GFRA2 and GDNF family receptor alpha 1 [5,6]. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) [7]. The, recombinant human G-DNF, expressed in CHO cells is disulfide-linked homo-dimer, with an apparent molecular weight of ca.30.4 kDa.</td></tr><tr><th>M.W.</th><td colspan="7"> 30.4 kDa (homo-dimer), observed by non-reducing SDS-PAGE.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% as analyzed by SDS-PAGE and HPLC.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> <0.2 EU/ug, determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> ED50 1 x 103 units/mg</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant, human Glial cell line-derived neurotrophic factor (G-DNF), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhG-DNF should be stable up to 1 week at 4C or up to 2 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized after extensive dialysis against PBS.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O or PBS at 100 ug/ml.</td></tr><tr><th>Sequence</th><td colspan="7"> Ser78 – Ile211 (Accession
Similar products	G-DNF
Lieferbar
Specificity	ED50 1 x 103 units/mg
Country of Origin	USA
Storage Conditions	Lyophilized recombinant, human Glial cell line-derived neurotrophic factor (G-DNF), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhG-DNF should be stable up to 1 week at 4C or up to 2 months at -20C.
Molecular Weight	30.4 kDa (homo-dimer), observed by non-reducing SDS-PAGE.
Product Line	Cytokine, Chemokines & Growth Factors
Manufacturer - Specificity	ED50 1 x 103 units/mg
Description	Glial cell line-derived neurotrophic factor (G-DNF), is a neurotrophic factors belong to TGF-beta super family necessary for neuron survival and phenotypic maintenance in central and peripheral nervous systems [1]. G-DNF, has the potent to support the differentiation and survival of many neuron subpopulations, prominent for dopaminergic neurons [2] and motor neurons [3], as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human [4]. GDNF has shown to interact with GFRA2 and GDNF family receptor alpha 1 [5, 6]. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) [7]. The, recombinant human G-DNF, expressed in CHO cells is disulfide-linked homo-dimer, with an apparent molecular weight of ca.30.4 kDa.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Endotoxin Level	<0.2 EU/ug, determined by LAL method.

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