G-DNF, Human

ArtNr	Z02927-50
Hersteller	GenScript
Menge	50 ug
Quantity options	1 mg 10 ug 50 ug
Kategorie	Neuroscience Neuroinflammation Metabolism Diabetes Neural Mitochondrial Function Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Protein Aggregation, Clearance & Misfolding Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Autophagy Cardiovascular Research Hypertension
Typ	Proteins
Specific against	Human (Homo sapiens)
Purity	> 95% as analyzed by SDS-PAGE and HPLC.
Sequence	Ser78 – Ile211 (Accession # P39905)
Citations	1. Pascual, A. et al. (2011) J Mol Endocrinol 46: R83-R92Gauldie, J. et al. (1987) Proc. Natl. Acad. Sci. USA, 84, 7251-7255. 2. Roussa E. et al. (2009) Adv Exp Med Biol. 651:81-90. 3. Hong M. et al. (2008) Expert Rev Neurother. 8:1125-39. 4. Gordon, T. (2009) Neurosurg Focus. 26:E3. 5. Jing, S. et al. (1997). J. Biol. Chem. 272 (52): 33111–7, 6. Cik, M. et al. (2000). J. Biol. Chem. 275: 27505–12, 7. Takahashi, M. et al. (2001). Cytokine Growth Factor Rev. 12:361-73.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02927_50-G_DNF_Human,Glial cell line-derived neurotrophic factor (G-DNF), is a neurotrophic factors belong to TGF-beta super family necessary for neuron survival and phenotypic maintenance in central and peripheral nervous systems [1]. G-DNF, has the potent to support the differentiation and survival of many neuron subpopulations, prominent for dopaminergic neurons [2] and motor neurons [3], as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human [4]. GDNF has shown to interact with GFRA2 and GDNF family receptor alpha 1 [5,6]. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) [7]. The, recombinant human G-DNF, expressed in CHO cells is disulfide-linked homo-dimer, with an apparent molecular weight of ca.30.4 kDa.</td></tr><tr><th>M.W.</th><td colspan="7"> 30.4 kDa (homo-dimer), observed by non-reducing SDS-PAGE.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% as analyzed by SDS-PAGE and HPLC.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> <0.2 EU/ug, determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> ED50 1 x 103 units/mg</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant, human Glial cell line-derived neurotrophic factor (G-DNF), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhG-DNF should be stable up to 1 week at 4C or up to 2 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized after extensive dialysis against PBS.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O or PBS at 100 ug/ml.</td></tr><tr><th>Sequence</th><td colspan="7"> Ser78 – Ile211 (Accession
Similar products	G-DNF
Lieferbar
Specificity	ED50 1 x 103 units/mg
Country of Origin	USA
Storage Conditions	Lyophilized recombinant, human Glial cell line-derived neurotrophic factor (G-DNF), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhG-DNF should be stable up to 1 week at 4C or up to 2 months at -20C.
Molecular Weight	30.4 kDa (homo-dimer), observed by non-reducing SDS-PAGE.
Product Line	Cytokine, Chemokines & Growth Factors
Manufacturer - Specificity	ED50 1 x 103 units/mg
Description	Glial cell line-derived neurotrophic factor (G-DNF), is a neurotrophic factors belong to TGF-beta super family necessary for neuron survival and phenotypic maintenance in central and peripheral nervous systems [1]. G-DNF, has the potent to support the differentiation and survival of many neuron subpopulations, prominent for dopaminergic neurons [2] and motor neurons [3], as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human [4]. GDNF has shown to interact with GFRA2 and GDNF family receptor alpha 1 [5, 6]. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) [7]. The, recombinant human G-DNF, expressed in CHO cells is disulfide-linked homo-dimer, with an apparent molecular weight of ca.30.4 kDa.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Endotoxin Level	<0.2 EU/ug, determined by LAL method.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkt-Datenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 50 ug

lieferbar

Lieferung vsl. bis 21.08.2025

Express-Lieferung: 3 Tage sparen

Vergleichen

Auf den Wunschzettel

Angebot anfordern