G-DNF, Human

Glial cell line-derived neurotrophic factor (G-DNF), is a neurotrophic factors belong to TGF-beta super family necessary for neuron survival and phenotypic maintenance in central and peripheral nervous systems [1]. G-DNF, has the potent to support the differentiation and survival of many neuron subpopulations, prominent for dopaminergic neurons [2] and motor neurons [3], as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human [4]. GDNF has shown to interact with GFRA2 and GDNF family receptor alpha 1 [5, 6]. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) [7]. The, recombinant human G-DNF, expressed in CHO cells is disulfide-linked homo-dimer, with an apparent molecular weight of ca.30.4 kDa.

Lyophilized after extensive dialysis against PBS.

Cytokine, Chemokines & Growth Factors

Lyophilized recombinant, human Glial cell line-derived neurotrophic factor (G-DNF), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhG-DNF should be stable up to 1 week at 4C or up to 2 months at -20C.