ArtNr |
Z02983-10 |
Hersteller |
GenScript
|
Menge |
10 ug |
Quantity options |
1 mg
10 ug
50 ug
|
Kategorie |
|
Typ |
Proteins |
Specific against |
Human (Homo sapiens) |
Purity |
> 95% as analyzed by SDS-PAGE and HPLC. |
Sequence |
Ala18-Glu144 (Accession # CAA26822). |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
protein/Z02983_10-Granulocyte_Macrophage_Colony_Stimulating_Factor_GM_CSF_Human,Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF), was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effectors functions of granulocytes,monocytes/macrophages and eosinophils. Human Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF), can induce human endothelial cells to migrate and proliferate. Additionally, Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) can stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma, and adenocarcinoma cell lines.</td></tr><tr><th>M.W.</th><td colspan="7"> 22-28 kDa, observed by non-reducing SDS-PAGE.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% as analyzed by SDS-PAGE and HPLC.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> < 0.2 EU/ug, determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> ED50, 5×106 units/mg.</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant, human Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhGM-CSF should be stable up to 1 week at 4C or up to 2 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized after extensive dialysis against PBS.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O or PBS at 100 ug/ml.</td></tr><tr><th>Sequence</th><td colspan="7"> Ala18-Glu144 (Accession |
Similar products |
Granulocyte |
Versandbedingung |
Gekühlt |
Lieferbar |
|
Specificity |
ED50, 5x106 units/mg. |
Manufacturer - Category |
Proteins |
Country of Origin |
USA |
Shipping Temperature |
4°C |
Storage Conditions |
-80°C |
Molecular Weight |
22-28 kDa, observed by non-reducing SDS-PAGE. |
Product Line |
Growth Factors |
Manufacturer - Specificity |
ED50, 5x106 units/mg. |
Description |
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF), was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effectors functions of granulocytes, monocytes/macrophages and eosinophils. Human Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF), can induce human endothelial cells to migrate and proliferate. Additionally, Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) can stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma, and adenocarcinoma cell lines. |
Reconstitution |
Reconstituted in ddH2O or PBS at 100 ug/ml. |
Formulation |
Lyophilized after extensive dialysis against PBS. |
Endotoxin Level |
< 0.2 EU/ug, determined by LAL method. |
Notes |
For research use only |
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