April, Mouse

ArtNr	Z02969-10
Hersteller	GenScript
Menge	10 ug
Quantity options	1 mg 10 ug 50 ug
Kategorie	Oncology By Cell Type Hematology Leukemia Myeloma Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Proliferation
Typ	Proteins
Specific against	Mouse (Murine, Mus musculus)
Purity	> 95% by SDS-PAGE and HPLC analyses
Sequence	Arg50--Leu241 -(accession number: Q9D777), expressed with an N-terminal Met.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02969_10-A_proliferation_inducing_ligand_April_Mouse,A Proliferation-inducing Ligand (April)), also known as TNSF13A, Tall-2, and TRDL-1, is a member of the TNF ligand (TNFL) superfamily. April is most similar to B-cell activation factor (BAFF) with which it shares 30% sequence identity, compete for two receptors, TACI and BCMA. APRIL is expressed at low levels in lymphoid tissue and is over-expressed by a number of tumors. April has a proliferative effect on both normal and tumor cell lines in vitro and in vivo. APRIL seems to be involved in the regulation of death and proliferation of tumor cells, but there are still contradictory findings regarding its overall biological effects.Recombinant mouse, A Proliferation-inducing Ligand (rmApril), produced in E. coli is a single non-glycosylated polypeptide chain containing 192 amino acids. A fully biologically active molecule, rmApril has a molecular mass of 21.9kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.</td></tr><tr><th>M.W.</th><td colspan="7"> 21.9kDa, observed by reducing SDS-PAGE.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% by SDS-PAGE and HPLC analyses</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> <0.2 EU/ug, determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> Measured by its ability to induce cell proliferation of RPMI 8226 Cells.</td></tr><tr><th>Storage</th><td colspan="7">Lyophilized recombinant, mouse A Proliferation-inducing Ligand (rmApril), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rmApril should be stable up to 2 weeks at 4C or up to 3 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized after extensive dialysis against 20mM acetic acid.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O at 100 ug/ml.</td></tr><tr><th>Sequence</th><td colspan="7"> Arg50--Leu241 -(accession number: Q9D777), expressed with an N-terminal Met.</td></tr>
Similar products	A
Versandbedingung	Gekühlt
Lieferbar
Specificity	Measured by its ability to induce cell proliferation of RPMI 8226 Cells.
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	21.9kDa, observed by reducing SDS-PAGE.
Product Line	Cytokines
Manufacturer - Specificity	Measured by its ability to induce cell proliferation of RPMI 8226 Cells.
Description	A Proliferation-inducing Ligand (April)), also known as TNSF13A, Tall-2, and TRDL-1, is a member of the TNF ligand (TNFL) superfamily. April is most similar to B-cell activation factor (BAFF) with which it shares 30% sequence identity, compete for two receptors, TACI and BCMA. APRIL is expressed at low levels in lymphoid tissue and is over-expressed by a number of tumors. April has a proliferative effect on both normal and tumor cell lines in vitro and in vivo. APRIL seems to be involved in the regulation of death and proliferation of tumor cells, but there are still contradictory findings regarding its overall biological effects.Recombinant mouse, A Proliferation-inducing Ligand (rmApril), produced in E. coli is a single non-glycosylated polypeptide chain containing 192 amino acids. A fully biologically active molecule, rmApril has a molecular mass of 21.9kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Reconstitution	Reconstituted in ddH2O at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against 20mM acetic acid.
Endotoxin Level	<0.2 EU/ug, determined by LAL method.

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