Interleukin-17 Receptor C (IL-17 RC), His, Mouse

USA

-80

Interleukin-17 receptor C (IL-17RC) , also known as interleukin-17 receptor–like (IL-17RL), forms a heterodimeric complex with IL-17RA to engage IL-17 ligand and promote IL-17 signaling. IL-17RC has 22% sequence homology with IL-17RA and is highly expressed in epithelial cells. IL-17RC can undergo alternative splicing generating several different variants, some of which a function has yet to be defined. High expression of IL-17RC has been detected in prostate cancer cells, however, IL-17 signaling has also been show to promote anti-tumor activity in certain types of cancer. Due to IL-17’s role in inflammation, IL-17RC has been indicated as having a potential role in certain autoimmune disease.
Recombinant mouse IL-17RC produced in CHO cells is a polypeptide chain containing 451 amino acids. A fully biologically active molecule, rmIL-17RC has a molecular mass of 58 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.