Vergleich

Interferon-tau ( IFN-tau ), Ovine Europäischer Partner

Hersteller GenScript
Kategorie
Typ Proteins
Specific against other
Format Sterile Filtered White lyophilized (freeze-dried) powder.
Menge 1mg
ArtNr Z02790-1
Targets FAM20C, HLA-C, MAPT
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Specificity
Fully biologically active when compared to IFN-alpha. The specific activity determined by a viral resistance assay is no less than 1.0 x 107 IU/mg.
Description
IFN-tau is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN- tau has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-ª/ß. The current investigation concerns the effect of recombinant ovine IFN- tau (rOvIFN- tau) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells. IFN- tau induced tyrosine phosphorylation of Stat1 and upregulated the expression of MHC class I on CVE. One proposed action by which type I IFN reduce the relapse rate in MS is via interference with IFN-I³-induced MHC class II expression. IFN- tau was shown to downregulate IFN-I³-induced MHC class II expression on CVE and, hence, may be of potential therapeutic value in downregulating inflammation in the central nervous system (CNS). IFN- tau did not upregulate the expression of MHC class II on CVE. IFN- tau also inhibited the replication of Theiler's virus in CVE.
Endotoxin Level
Less than 0.2EU/ug of rOvIFN-tau as determined by LAL method.
Formulation
Lyophilized from a 0.2µ, m filtered concentrated, solution in PBS, pH 7.4.
M.W.
Approximately 19.9 kDa, a single non-glycosylated polypeptide chain containing 172 amino acids.
Product Line
Cytokine, Chemokines & Growth Factors
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °, C. Further dilutions should be made in appropriate buffered solutions.
Storage
This lyophilized preparation is stable at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles.
Usage
This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Product Origin
USA

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 1mg
Lieferbar: In stock
lieferbar

Lieferung vsl. bis 16.05.2024 

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