Interferon-tau (IFN-tau), Ovine Europäischer Partner

Hersteller GenScript
Typ Proteins
Specific against other
Format Sterile Filtered White lyophilized (freeze-dried) powder.
Menge 10ug
ArtNr Z02790-10
Targets FAM20C, HLA-C, MAPT
eClass 6.1 34160400
eClass 9.0 42020190
Fully biologically active when compared to IFN-alpha. The specific activity determined by a viral resistance assay is no less than 1.0 x 107 IU/mg.
IFN-tau is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN- tau has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-ª/ß. The current investigation concerns the effect of recombinant ovine IFN- tau (rOvIFN- tau) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells. IFN- tau induced tyrosine phosphorylation of Stat1 and upregulated the expression of MHC class I on CVE. One proposed action by which type I IFN reduce the relapse rate in MS is via interference with IFN-I³-induced MHC class II expression. IFN- tau was shown to downregulate IFN-I³-induced MHC class II expression on CVE and, hence, may be of potential therapeutic value in downregulating inflammation in the central nervous system (CNS). IFN- tau did not upregulate the expression of MHC class II on CVE. IFN- tau also inhibited the replication of Theiler's virus in CVE.
Endotoxin Level
Less than 0.2EU/ug of rOvIFN-tau as determined by LAL method.
Lyophilized from a 0.2µ, m filtered concentrated, solution in PBS, pH 7.4.
Approximately 19.9 kDa, a single non-glycosylated polypeptide chain containing 172 amino acids.
Product Line
Cytokine, Chemokines & Growth Factors
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °, C. Further dilutions should be made in appropriate buffered solutions.
This lyophilized preparation is stable at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles.
This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Product Origin

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10ug
Lieferbar: In stock

Lieferung vsl. bis 16.05.2024 


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