RABBIT ANTI HUMAN CTGF

CTGF

Phosphate buffered saline pH7. 2

Recombinant human CTGF.

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts myofibroblasts endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Ref. 13Ref. 14Subunit structureMonomer. Subcellular locationSecreted & rsaquo; extracellular space & rsaquo; extracellular matrix By similarity. Secreted By similarity. Tissue specificityExpressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. Ref. 12Sequence similaritiesBelongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain. 1. Colonna M. et al. (1999) A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells. J. Leukoc. Biol. 66: 375-381. 2. Borges L. et al. (1997) A family of human lymphoid and myeloid Ig-like receptors some of which bind to MHC class I molecules. J. Immunol. 159: 5192-5196. [1] \" Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. \" Arm J. P. Nwankwo C. Austen K. F. J. Immunol. 159:2342-2349(1997) [PubMed: 9278324] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANTS ARG-59; GLU-90; ASN-122; GLN-205; HIS-405; GLN-539 AND VAL-574. Tissue: Monocyte. [2] \" A family of human lymphoid and myeloid Ig-like receptors some of which bind to MHC class I molecules. \" Borges L. Hsu M. -L. Fanger N. Kubin M. Cosman D. J. Immunol. 159:5192-5196(1997) [PubMed: 9548455] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANT ARG-400 TISSUE SPECIFICITY. Tissue: Peripheral blood leukocyte. [3] \" Genomics and diversity of the immunoglobulin-like transcript 5 locus. \" Cuillerier B. Bahram S. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2) VARIANTS GLU-90; GLN-205; ARG-400; HIS-405; GLN-539 AND VAL-574. [4] \" Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. \" Wende H. Volz A. Ziegler A. Immunogenetics 51:703-713(2000) [PubMed: 10941842] [Abstract]Cited for: IDENTIFICATION IN THE LRC. [5] ErratumWende H. Volz A. Ziegler A. Immunogenetics 52:3-4(2001) [6] \" Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. \" Yu L. -R. Zhu Z. Chan K. C. Issaq H. J. Dimitrov D. S. Veenstra T. D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract]Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-480 MASS SPECTROMETRY. Tissue: Cervix carcinoma.