RABBIT ANTI HUMAN ANNEXIN I

ANNEXIN I

Phosphate buffered saline

6xHis-tagged full-length recombinant human ANXA1 (NP_000691. 1).

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity. Subunit structureHomodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF By similarity. Ref. 7Subcellular locationNucleus By similarity. Cytoplasm By similarity. Cell projection & rsaquo; cilium By similarity. Basolateral cell membrane By similarity.

A pair of annexin repeats may form one binding site for calcium and phospholipid. Post-translational modificationPhosphorylated by protein kinase C epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity. Ref. 5Ref. 8Ref. 9Ref. 10Ref. 11Ref. 13Sequence similaritiesBelongs to the annexin family. Contains 4 annexin repeats. 1. Woodfield R. et al. (2001) The p85 subunit of phosphoinositide 3-kinase is associated with beta-catenin in the cadherin-based adhesion complex. Biochem. J. 360: 335 - 344. 2. Reif. K. et al. (1993) Divergent regulation of phosphatidylinositol 3-Kinase P85 alpha and P85 beta isoforms upon T cell activation. J. Biol. Chem. 278:10780-10788. [1] \" Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. \" Skolnik E. Y. Margolis B. Mohammadi M. Lowenstein E. Fischer R. Drepps A. Ullrich A. Schlessinger J. Cell 65:83-90(1991) [PubMed: 1849461] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [2] \" Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. \" Antonetti D. A. Algenstaedt P. Kahn C. R. Mol. Cell. Biol. 16:2195-2203(1996) [PubMed: 8628286] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4) INTERACTION WITH IRS1 TISSUE SPECIFICITY. Tissue: Skeletal muscle. [3] Udelhoven M. Kotzka J. Knebel B. Klein E. Krone W. Mueller-Wieland D. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Skeletal muscle. [4] Totoki Y. Toyoda A. Takeda T. Sakaki Y. Tanaka A. Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2) VARIANT ILE-326. Tissue: Brain. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2) VARIANT LYS-451. Tissue: Placenta and Skeletal muscle. [6] \" Direct activation of the phosphatidylinositol 3\' -kinase by the insulin receptor. \" Van Horn D. J. Myers M. G. Jr. Backer J. M. J. Biol. Chem. 269:29-32(1994) [PubMed: 8276809] [Abstract]Cited for: INTERACTION WITH INSR. [7] \" Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. \" Craparo A. O\' Neill T. J. Gustafson T. A. J. Biol. Chem. 270:15639-15643(1995) [PubMed: 7541045] [Abstract]Cited for: INTERACTION WITH IGF1R. [8] \" Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. \" Gustafson T. A. He W. Craparo A. Schaub C. D. O\' Neill T. J. Mol. Cell. Biol. 15:2500-2508(1995) [PubMed: 7537849] [Abstract]Cited for: INTERACTION WITH INSR. [9] \" LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. \" Zhang W. Sloan-Lancaster J. Kitchen J. Trible R. P. Samelson L. E. Cell 92:83-92(1998) [PubMed: 9489702] [Abstract]Cited for: INTERACTION WITH LAT. [10] \" Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells. \" Fantin V. R. Sparling J. D. Slot J. W. Keller S. R. Lienhard G. E. Lavan B. E. J. Biol. Chem. 273:10726-10732(1998) [PubMed: 9553137] [Abstract]Cited for: INTERACTION WITH IRS4.