MOUSE ANTI HUMAN CD2:Biotin

CD2

Purified IgG prepared by affinity chromatography on Protein A.

Is a single chain transmembrane glycoprotein of 50kD expressed by T cells NK cells and thymocytes. CD2 is a receptor for CD58 (LFA-3) and is important in mediating the interaction between T cells and target cells or antigen presenting cells.

CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells the cytoplasmic domain is implicated in the signaling function. Subunit structureInteracts with CD2AP By similarity. Interacts with PSTPIP1. Ref. 11Subcellular locationMembrane; Single-pass type I membrane protein. Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Bellingan. G. et al. (2002) Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J. Exp. Med. 196:1515-1521.