MOUSE ANTI HUMAN CD24

GWB-A5017B

IgG1

Phosphate buffered saline pH7. 4

Glycoproteins purified from human NALM-1 cell line

Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells and prevents their terminal differentiation into antibody-forming cells. Ref. 7Subunit structureInteracts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line LYN in the erythroleukemia cell line K562 and in Burkitt\' s lymphoma. Ref. 7Ref. 6Subcellular locationCell membrane; Lipid-anchor & rsaquo; GPI-anchor. Tissue specificityB-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. Ref. 6Ref. 9Induction: Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells. Post-translational modificationExtensively O-glycosylated. Involvement in diseaseGenetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial inflammatory demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat mediated by both cellular and humoral immunity. Clinical manifestations include visual loss extra-ocular movement disorders paresthesias loss of sensation weakness dysarthria spasticity ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations perhaps by affecting the efficiency of CD24 expression on the cell surface. Ref. 9Sequence similaritiesBelongs to the CD24 family. Sequence cautionThe sequence AAD14170. 1 differs from that shown. Reason: Erroneous initiation. 1. Winter M. J. et al. (2003) The epithelial cell adhesion molecule (Ep - CAM) as a morphoregulatory molecule is a tool in surgical pathology. Am. J. Pathol. 163: 2139-2148. 2. Koga Y. et al. (2008) Improved recovery of exfoliated colonocytes from feces using newly developed immunomagnetic beads. Gastroenterol. Res. Pract. 2008: 605273 [1] \" Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA. \" Strnad J. Hamilton A. E. Beavers L. S. Gamboa G. C. Apelgren L. D. Taber L. D. Sportsman J. R. Bumol T. F. Sharp J. D. Gadski R. A. Cancer Res. 49:314-317(1989) [PubMed: 2463074] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT THR-115. Tissue: Lung adenocarcinoma. [2] \" Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker. \" Perez M. S. Walker L. E. J. Immunol. 142:3662-3667(1989) [PubMed: 2469722] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT THR-115. [3] \" Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen a matrix adhesion protein. \" Simon B. Podolsky D. K. Moldenhauer G. Isselbacher K. J. Gattoni-Celli S. Brand S. J. Proc. Natl. Acad. Sci. U. S. A. 87:2755-2759(1990) [PubMed: 2108441] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT THR-115. [4] \" Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2. \" Szala S. Froehlich M. Scollon M. Kasai Y. Steplewski Z. Koprowski H. Linnenbach A. J. Proc. Natl. Acad. Sci. U. S. A. 87:3542-3546(1990) [PubMed: 2333300] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon carcinoma. [5] \" Retroposition in a family of carcinoma-associated antigen genes. \" Linnenbach A. J. Seng B. A. Wu S. Robbins S. Scollon M. Pyrc J. J. Druck T. Huebner K. Mol. Cell. Biol. 13:1507-1515(1993) [PubMed: 8382772] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Lymphoma. [6] \" Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). \" Halleck A. Ebert L. Mkoundinya M. Schick M. Eisenstein S. Neubert P. Kstrang K. Schatten R. Shen B. Henze S. Mar W. Korn B. Zuo D. Hu Y. LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [7] \" Generation and annotation of the DNA sequences of human chromosomes 2 and 4. \" Hillier L. W. Graves T. A. Fulton R. S. Fulton L. A. Pepin K. H. Minx P. Wagner-McPherson C. Layman D. Wylie K. Sekhon M. Becker M. C. Fewell G. A. Delehaunty K. D. Miner T. L. Nash W. E. Kremitzki C. Oddy L. Du H. Sun H. Bradshaw-Cordum H. Ali J. Carter J. Cordes M. Harris A. Isak A. van Brunt A. Nguyen C. Du F. Courtney L. Kalicki J. Ozersky P. Abbott S. Armstrong J. Belter E. A. Caruso L. Cedroni M. Cotton M. Davidson T. Desai A. Elliott G. Erb T. Fronick C. Gaige T. Haakenson W. Haglund K. Holmes A. Harkins R. Kim K. Kruchowski S. S. Strong C. M. Grewal N. Goyea E. Hou S. Levy A. Martinka S. Mead K. McLellan M. D. Meyer R. Randall-Maher J. Tomlinson C. Dauphin-Kohlberg S. Kozlowicz-Reilly A. Shah N. Swearengen-Shahid S. Snider J. Strong J. T. Thompson J. Yoakum M. Leonard S. Pearman C. Trani L. Radionenko M. Waligorski J. E. Wang C. Rock S. M. Tin-Wollam A. -M. Maupin R. Latreille P. Wendl||?||M. C. Yang S. -P. Pohl C. Wallis J. W. Spieth J. Bieri T. A. Berkowicz N. Nelson J. O. Osborne J. Ding L. Meyer R. Sabo A. Shotland Y. Sinha P. Wohldmann P. E. Cook L. L. Hickenbotham M. T. Eldred J. Williams D. Jones T. A. She X. Ciccarelli F. D. Izaurralde E. Taylor J. Schmutz J. Myers R. M. Cox D. R. Huang X. McPherson J. D. Mardis E. R. Clifton S. W. Warren W. C. Chinwalla A. T. Eddy S. R. Marra M. A. Ovcharenko I. Furey T. S. Miller W. Eichler E. E. Bork P. Suyama M. Torrents D. Waterston R. H. Wilson R. K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [8] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [9] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT THR-115. Tissue: Ovary. [10] \" Sequence investigation of the major gastrointestinal tumor-associated antigen gene family GA733. \" Linnenbach A. J. Wojcierowski J. Wu S. Pyrc J. J. Ross A. H. Dietzschold B. Speicher D. Koprowski H. Proc. Natl. Acad. Sci. U. S. A. 86:27-31(1989) [PubMed: 2911574] [Abstract]Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-126. Tissue: Placenta.