RABBIT ANTI HUMAN GALECTIN-3:Biotin

GWB-23F6CF

Polyclonal IgG

Specifically recognises human Galectin-3 (Gal-3) a member of the galectin family of beta-galactoside-binding proteins which is involved in both intracellular and extracellular functions and exhibits anti-apoptotic properties. Gal-3 is implicated in many biological processes including cell differentiation growth adhesion angiogenesis and inflammation and is expressed in a wide range of neoplasms. Gal-3 acts as a regulator of tumour metastasis and several studies have shown a correlation between levels of Gal-3 and tumour progression in liver thyroid colon gastric and breast carcinomas making Gal-3 an emerging cancer marker. Recommended Positive Controls: RECOMBINANT HUMAN GALECTIN-3Recommended Secondary Antibodies: STREPTAVIDIN

Cytoplasmic in adenomas and carcinomas. May be secreted by a non-classical secretory pathway and associate with the cell surface. Ref. 15Ref. 5Tissue specificityA major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Sequence similaritiesContains 1 galectin domain. 1. Casey T. et al. (2007) Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome. Mol. Cell. Proteomics 6: 767-780. [1] \" Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. \" Hotta H. Ross A. H. Huebner K. Isobe M. Wendeborn S. Chao M. V. Ricciardi R. P. Tsujimoto Y. Croce C. M. Koprowski H. Cancer Res. 48:2955-2962(1988) [PubMed: 3365686] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" Characterization of three abundant mRNAs from human ovarian granulosa cells. \" Rapp G. Freudenstein J. Klaudiny J. Mucha J. Wempe F. Zimmer M. Scheit K. H. DNA Cell Biol. 9:479-485(1990) [PubMed: 2171551] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary. [3] \" CD63 antigen. A novel lysosomal membrane glycoprotein cloned by a screening procedure for intracellular antigens in eukaryotic cells. \" Metzelaar M. J. Wigngaard P. L. Peters P. J. Sixma J. J. Nieuwenhuis H. K. Clevers H. C. J. Biol. Chem. 266:3239-3245(1991) [PubMed: 1993697] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] SUBCELLULAR LOCATION. [4] \" An ocular melanoma-associated antigen. Molecular characterization. \" Wang M. X. Earley J. J. Jr. Shields J. A. Donoso L. A. Arch. Ophthalmol. 110:399-404(1992) [PubMed: 1339263] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] \" Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5\' -flanking regulatory sequences. \" Hotta H. Miyamoto H. Hara I. Takahashi N. Homma M. Biochem. Biophys. Res. Commun. 185:436-442(1992) [PubMed: 1599482] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [6] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle. [7] \" Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). \" Halleck A. Ebert L. Mkoundinya M. Schick M. Eisenstein S. Neubert P. Kstrang K. Schatten R. Shen B. Henze S. Mar W. Korn B. Zuo D. Hu Y. LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [8] \" Cloning of human full-length CDSs in BD Creator(TM) system donor vector. \" Kalnine N. Chen X. Rolfs A. Halleck A. Hines L. Eisenstein S. Koundinya M. Raphael J. Moreira D. Kelley T. LaBaer J. Lin Y. Phelan M. Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [9] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [10] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Muscle.