Mouse Monoclonal Antibody to BLK

BLK ( B lymphoid tyrosine kinase) with 505-amino acid protein (about 56KDa) belongs to the Src non-receptor tyrosine kinases family. Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis cytoskeletal organization and membrane trafficking. Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus sustained activation of Blk induces responses normally associated with the pre-BCR.

9D10D1

Ascitic fluid containing 0. 03% sodium azide.