Mouse Monoclonal Antibody to ETV1

ETV1: ets variant gene 1. Several members of the Ets gene family encode sequence-specific DNA binding proteins that recognize DNA sequences with a centrally located 5\' -GGAA-3\' element. All of the Ets proteins recognize the same central core sequence but each protein interacts with unique sequences that flank this core. ER81 (also designated ETV1) binds the motif 5\' -CGGAA/T-3\' . ER81 is highly expressed in brain testis lung and heart. ER81 is also moderately expressed in spleen pancreas colon and small intestine. During development ER81 displays a unique expression patterns which suggests that this transcriptional factor might play an important role in organogenesis. ERK-1 activates ER81 transcriptional activity while MAPKAP kinase 2 inhibits ER81.

1C8B6

Ascitic fluid containing 0. 03% sodium azide. Application: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test. 1. Neoplasia. 2006 Oct; 8(10):826-32. 2. Cancer Genet Cytogenet. 2008 May; 183(1):21-7.