Vergleich

Rat Anti-Mouse CD49d/VLA-4

ArtNr 20-787-275178
Hersteller GENWAY
Menge 0.5 mg
Kategorie
Typ Antibody
Applikationen FC, IHC
Clon PS/2
Specific against Mouse (Murine, Mus musculus)
Host Rat
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-6070CF
Similar products 20-787-275178
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Genway ID:
GWB-6070CF
Isotype:
Rat IgG2b kappa
Clone:
PS/2
Characterization:
To ensure lot-to-lot consistency each batch of monoclonal antibody is tested for conformance to characteristics of a standard reference reagent using immunofluorescence staining and analysis by flow cytometry on a Becton Dickinson FACScan?. Representative data are included in this technical bulletin.
Specificity:
CD49d the 4 chain (100 kDa) of the VLA-4 integrin heterodimer (Mr 150-kDa)VLA-4 belongs to the 1-integrin family which functions both as cell-matrix and cell-cell receptors. 1-3 As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. 1 2 In addition to CD44/pgp-1 VLA-4 has been shown to be important for lymphopoiesis and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. 2 3 CD49d/VLA-4 is expressed in low amounts on resting lymphocytes and monocytes is absent or minimally detectable on stromal cells whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive. 1 2 Antibody PS/2 also reacts with human VLA-4. 1
Warning:
Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin eyes or clothing. Wear eye or face protection when handling. If skin or eye contact occurs wash with copious amounts of water. If ingested or inhaled contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing. 1. Miyake K. I. L. Weissman J. S. Greenberger and P. W. Kincade. 1991. J. Exp. Med. 173:599. 2. Christensen J. P. E. C. Andersson A. Scheynius O. Marker and A. R. Thomsen. 1995. J. Immunol. 154:5293. 3. Henseleit U. K. Steinbrink C. Sunderkotter M. Goebeler J. Roth and C. Sorg. 1994. Exp. Dermatol. 3:249 4. Lauri D. C. De Giovanni T. Biondelli E. Lalli L. Landuzzi A. Facchini G. Nicoletti P. Nanni E. Dejana and P. L. Lollini. 1993. Br. J. Cancer 68:862.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 0.5 mg
Lieferbar: In stock
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