WW domain-containing transcription regulator protein 1

Reacts with residues 386-400 [VESALNKSEPFLTWL] which is the PDZ-binding domain of the 49kDa human TAZ protein. Reacts with mouse and rat.

Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP (By similarity).

Highly expressed in kidney heart placenta and lung.

Binds to transcription factors via its WW domain.

Contains 1 WW domain. [1] Hong J. H. Hwang E. S. McManus M. T. Amsterdam A. Tian Y. Kalmukova R. Mueller E. Benjamin T. Spiegelman B. M. Sharp P. A. et al. TAZ a transcriptional modulator of mesenchymal stem cell differentiation[2] Howell M. Borchers C. and Milgram S. L. et al. Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription[3] Kanai F. Marignani P. A. Sarbassova D. Yagi R. Hall R. A. Donowitz M. Hisaminato A. Fujiwara T. Ito Y. Cantley L. C. and et al. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins[4] Kanai F. Marignani P. A. Sarbassova D. Yagi R. Hall R. A. Donowitz M. Hisaminato A. Fujiwara T. Ito Y. Cantley L. C. and et al. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins[5] Kanai F. Marignani P. A. Sarbassova D. Yagi R. Hall R. A. Donowitz M. Hisaminato A. Fujiwara T. Ito Y. Cantley L. C. et al. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. [6] Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. et al. Complete sequencing and characterization of 21 243 full-length human cDNAs. [7] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences.