F-box only protein 17

GWB-87C766

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity).

Expressed in heart skeletal muscle liver and kidney. Expressed at lower levels in spleen and brain.

Contains 1 FBA (F-box associated) domain. Summary: This protein is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box) which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains Fbls containing leucine-rich repeats and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing of this gene results in 2 transcript variants encoding different isoforms. [1] Ilyin G. P. Serandour A. L. Pigeon C. Rialland M. Glaise D. and Guguen-Guillouzo C. A new subfamily of structurally related human F-box proteins[2] Kipreos E. T. and Pagano M. et al. The F-box protein family[3] Ilyin G. P. Serandour A. L. Pigeon C. Rialland M. Glaise D. Guguen-Guillouzo C. A new subfamily of structurally related human F-box proteins. [4] Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. et al. Complete sequencing and characterization of 21 243 full-length human cDNAs. [5] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences.