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GTF2B (general transcription factor IIB)

GTF2B (general transcription factor IIB)

ArtNr	18-003-43059
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody
Applikationen	WB, IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-80AFF6
Similar products	18-003-43059
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Genway ID:	GWB-80AFF6
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of human GTF2B.
ELISA Titre:	1:312500
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. GTF2B is the general transcription factor IIB. one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA
Function:	General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. Cofactor: Binds 1 zinc ion per subunit.
Subunit:	Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1 (By similarity).
Subcellular Location:	Nucleus.
Similarity:	Belongs to the TFIIB family.
Similarity:	Contains 1 TFIIB-type zinc finger. Summary: This protein is the general transcription factor IIB one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID the factor which initially recognizes the promoter sequence and RNA polymerase II. Tubon. T. C. . et al. . (2004) Mol. Cell. Biol. 24 (7). 2863-2874.

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