SIRT5 (sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae))

GWB-1FB3C4

1:62500

Contains 1 deacetylase sirtuin-type domain. Summary: This protein is a member of the sirtuin family of proteins homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in two transcript variants. Mahlknecht. U. . et al. . (2006) Cytogenet. Genome Res. 112 (3-4). 208-212.