Ribosomal protein L22

GWB-6DD8DC

Peptide with sequence C-SKESYELRYFQINQ from the C Terminus of the Notes: Peptide ELISA: antibody detection limit dilution 1:16 000. Western Blot: Preliminary experiments gave bands at approx 17-18kDa and 25kDa in Human Liver lysates after 0. 5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 14. 8kDa according to NP_000974. 1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands). Summary: Ribosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This protein is a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3; 21 translocations; however these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26 and this gene actually maps to 1p36. 3-p36. 2. [1] Fok V. Mitton-Fry R. M. Grech A. and Steitz J. A. et al. Multiple domains of EBER 1 an Epstein-Barr virus noncoding RNA recruit human ribosomal protein L22[2] Nakao K. Mochiki M. Nibu K. Sugasawa M. and Uozaki H. et al. Analysis of prognostic factors of nasopharyngeal carcinoma: impact of in situ hybridization for Epstein-Barr virus encoded small RNA 1[3] Andersen J. S. Lam Y. W. Leung A. K. Ong S. E. Lyon C. E. Lamond A. I. and Mann M. Nucleolar proteome dynamics[4] Chen K. C. Chiang H. S. and Fang C. L. et al. EBER expression of pure urinary bladder lymphoepithelioma-like carcinoma in two unique Asian patients[5] Kapp L. D. and Lorsch J. R. et al. The molecular mechanics of eukaryotic translation