NORE1

ArtNr	18-272-196564
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Breast Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-FE98B6
Similar products	18-272-196564
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Genway ID:	GWB-FE98B6
Isotype:	IgG
Immunogen:	Synthetic peptide: DNPQKFALFKRIHKDGQ corresponding to amino acids 313-329 of NORE1. This sequence is located in the RA domain of NORE1 and is 100% conserved between human rat and mouse.
Antigen Species:	Human
Target:	NORE1
Concentration:	1 mg/ml Storage
Preservative:	0. 02% Sodium Azide; Constituents: PBS
Application Note:	WB: Use at a dilution of 1/500 - 1/1000. Predicted
Molecular Weight:	47 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. RASSF1A a new tumor-suppressor gene located at 3p21. 3 is frequently inactivated by promoter region hypermethylation in a variety of human cancers including lung breast kidney and neuroblastoma. Another member of the RASSF1 gene family Ras effector NORE1 which is structurally related to RASSF1 can also mediate a Ras-dependent apoptosis. Moreover an analysis of NORE1 protein expression showed that it is frequently down-regulated in lung tumor cell lines and primary lung tumors.
Function:	Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1 resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.
Subunit:	Interacts directly with activated HRAS1; a RASSF5-STK4 complex probably associates with activated HRAS1. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS RRAS2 MRAS RAP1B RAP2A and RALA. Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS1 (By similarity). Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1. Binds STK4/MST1 inhibiting STK4 autoactivation.
Subcellular Location:	Cytoplasm. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
Tissue Specificity:	Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
Similarity:	Contains 1 phorbol-ester/DAG-type zinc finger.
Similarity:	Contains 1 Ras-associating domain.
Similarity:	Contains 1 SARAH domain.

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