c-Kit phospho Y936

GWB-4167A3

Synthetic phosphopeptide derived from a region of human c Kit that contains tyrosine 936.

M07e cells + or - SCF

Type I membrane protein.

0. 05% Sodium Azide; Constituents: 50% Glycerol PBS 1mg/ml BSA. pH 7. 3

Type I membrane protein. c Kit also known as CD117 and stem cell factor receptor is a 145 kDa transmembrane tyrosine kinase encoded by the c Kit proto-oncogene. c Kit acts to regulate a variety of biological responses including cell proliferation apoptosis chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain and activation. c Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease gastrointestinal stromal tumor acute myeloid leukemia Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 936 of c Kit allows binding of Grb2 and activation of the Ras Raf ERK1& 2 signaling pathway.

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Membrane; Single-pass type I membrane protein.

Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764].

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Contains 1 protein kinase domain.