IP10

ArtNr	18-272-197581
Hersteller	GENWAY
Menge	0.025 mg
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Bone Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-C61241
Similar products	18-272-197581
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Genway ID:	GWB-C61241
Isotype:	IgG
Immunogen:	Recombinant full length protein (Rat).
Antigen Species:	Rat
Target:	IP10
Localization:	Secreted
Concentration:	1 mg/ml Storage
Preservative:	0. 1% Sodium Azide; Constituents: PBS
Application Note:	WB: Use at a dilution of 1/5000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Secreted IP-10 (interferon-gamma induced protein 10 kD; in mouse also called cytokine responsive gene 2 Crg-2 or mob-1) is a highly inducible primary response gene that belongs to the CXC chemokine superfamily. It was first cloned in 1985 (ref 1). The biological functions of IP-10 are still unclear. Like Mig IP-10 has no activity on neutrophils. Its functions include stimulation of monocytes natural killer and T-cell migration regulation of T-cell and bone marrow progenitor maturation modulation of adhesion molecule expression as well as inhibition of angiogenesis. Mig and IP-10 share the same receptor CXCR3 (ref 2 3).
Function:	Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
Subcellular Location:	Secreted.
Induction:	By interferon gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the interferon gamma response.
Ptm:	CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes. Mass Spectrometry: Mass=8641. 8; Method=Electrospray; Range=22-98; Source=PubMed:11559369; .
Similarity:	Belongs to the intercrine alpha (chemokine CxC) family.

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Menge: 0.025 mg

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