Vasopressin receptor type 2

3rd cytoplasmic domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (26 ug/ml) (Optimal dilution to be determined by the researcher)

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The human AVPR2 locus encodes the vasopressin receptor type 2 also known as the V2 receptor located in cytogenetic band Xq28. The gene\' s three exons and two introns are contained within 2. 1 kilobases. The L1CAM gene lies some 29 kb centromeric to AVPR2 and the C1 gene immediately teleomeric. Both are apparently transcribed in opposite orientation to AVPR2 (see NID g1302657). The AVPR2 protein product belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily and it couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor the V1a and V1b vasopressin receptors the oxytocin receptor and isotocin and mesotocin receptors in non-mammals is well conserved though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule predominantly in the distal convoluted tubule and collecting ducts where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these \' extrarenal receptors\' are stimulated by infusion of a V2 selective agonist (dDAVP) a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. AVPR2 expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [1] Slusarz M. J. Slusarz R. and Ciarkowski J. et al. Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system[2] Robben J. H. Sze M. Knoers N. V. and Deen P. M. et al. Rescue of vasopressin V2 receptor mutants by chemical chaperones: specificity and mechanism[3] Soylu A. Kasap B. Ogun N. Ozturk Y. Turkmen M. Hoefsloot L. and Kavukcu S. Efficacy of COX-2 inhibitors in a case of congenital nephrogenic diabetes insipidus[4] Thielen A. Oueslati M. Hermosilla R. Krause G. Oksche A. Rosenthal W. and Schulein R. The hydrophobic amino acid residues in the membrane-proximal C tail of the G protein-coupled vasopressin V2 receptor are necessary for transport-competent receptor folding[5] Gouill C. L. Darden T. Madziva M. T. and Birnbaumer M. et al. A role for K268 in V2R folding[6] Birnbaumer M. Seibold A. Gilbert S. Ishido M. Barberis C. Antaramian A. Brabet P. Rosenthal W. Molecular cloning of the receptor for human antidiuretic hormone. [7] Fay M. J. Du J. Yu X. North W. G. Evidence for expression of vasopressin V2 receptor mRNA in human lung. [8] Seibold A. Brabet P. Rosenthal W. Birnbaumer M. Structure and chromosomal localization of the human antidiuretic hormone receptor gene. [9] Du J. Fay M. J. Yu X. North W. G. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.