OTTHUMP00000018219

GWB-67607A

1 mg/ml
Summary of Expression: LGR8 has been reported in blood bone marrow brain kidney muscle tests thyroid and uterus. Ligand: INSL3 a Relaxin and Relaxin-like factor. Uses: IHC (18 ug/ml) (Optimal dilution to be determined by the researcher) Summary: The receptors for glycoprotein hormones such as follicle-stimulating hormone (FSH; see MIM 136530) and thyroid-stimulating hormone (TSH; see MIM 188540) are G protein-coupled 7-transmembrane receptors (GPCRs) with large N-terminal extracellular domains. Leucine-rich repeat (LRR)-containing GPCRs (LGRs) form a subgroup of the GPCR superfamily. [supplied by OMIM]. [1] Bathgate R. A. Ivell R. Sanborn B. M. Sherwood O. D. and Summers R. J. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides[2] Muda M. He C. Martini P. G. Ferraro T. Layfield S. Taylor D. Chevrier C. Schweickhardt R. Kelton C. Ryan P. L. and et al. Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity[3] Bathgate R. A. Ivell R. Sanborn B. M. Sherwood O. D. and Summers R. J. Receptors for relaxin family peptides[4] Bullesbach E. E. and Schwabe C. et al. LGR8 signal activation by the relaxin-like factor[5] Vinci G. Anjot M. N. Trivin C. Lottmann H. Brauner R. and McElreavey K. An analysis of the genetic factors involved in testicular descent in a cohort of 14 male patients with anorchia[6] Phillimore B. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. [7] Pelan S. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.