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Rabbit A\&#039, Alkaline Phosphatase

Rabbit A\&#039, Alkaline Phosphatase

Catalytic
ArtNr	18-511-244512
Hersteller	GENWAY
Menge	50 mg
Kategorie	Antibodies ELISA Primary Antibodies
Typ	Antibody
Applikationen	ELISA
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-6969A1
Similar products	18-511-244512
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Genway ID:	GWB-6969A1
Host Animal:	Rabbit
Immunogen:	Alkaline Phosphatase (Calf Intestine)
Specificity:	Alkaline Phosphatase Calf Intestine
Specificity:	Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum as well as purified and partially purified Alkaline Phosphatase [Calf Intestine]. Cross reactivity against Alkaline Phosphatase from other tissues and species may occur but have not been specifically determined.
Type of Product:	Polyclonal Antibodies to Assay Detection and Miscellaneous Reagents
Concentration:	10mg/ml (OD280nm) (prior to lyophilization)Preservatives: NaN3
Buffer:	Lyophilized from 0. 02M Potassium Phosphate 0. 15M Sodium Chloride pH 7. 2Applications Notes : Assayed against 1. 0ug of Alkaline Phosphatase (Calf Intestine) in standard ELISA using Peroxidase conjugated Affinity Purified Goat anti Rabbit IgG (H& L) and ABTS as a substrate for 30 minutes at room temperature. A working dilution of 1:3 000 to 1:15 000 of the reconstitution concentration is suggested for this product. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Rabbit A\' Alkaline Phosphatase. Rabbit Antibody to Alkaline Phosphatase (Calf Intestine)
Function:	This isozyme may play a role in skeletal mineralization.
Activity:	A phosphate monoester + H2O = an alcohol + phosphate. Cofactor: Binds 1 magnesium ion (By similarity). Cofactor: Binds 2 zinc ions (By similarity).
Subunit:	Homodimer.
Subcellular Location:	Cell membrane; Lipid-anchor GPI-anchor.
Ptm:	Glycosylated.
Disease:	Defects in ALPL are a cause of hypophosphatasia infantile (hypophosphatasia) [MIM:241500]; an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished depending on the age of onset: perinatal infantile childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth but with no bone disease are regarded as having odontohypophosphatasia (odonto).
Disease:	Defects in ALPL are a cause of hypophosphatasia childhood (hypophosphatasia) [MIM:241510].
Disease:	Defects in ALPL are a cause of hypophosphatasia adult type (hypophosphatasia) [MIM:146300].
Miscellaneous:	In most mammals there are four different isozymes: placental placental-like intestinal and tissue non-specific (liver/bone/kidney).
Similarity:	Belongs to the alkaline phosphatase family.

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Menge: 50 mg

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