CD156c

GWB-B0692B

102

Peptide corresponding to amino acids 732-748 of human CD156c.

Phosphate buffered saline

Suggested

Cleaves the membrane-bound precursor of TNF-alpha at \' 76-Ala-|-Val-77\' to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins including heparin-binding epidermal growth-like factor ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity).

Interacts with ephrin-A2 (By similarity).

Expressed in spleen lymph node thymus peripheral blood leukocyte bone marrow cartilage chondrocytes and fetal liver.

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Contains 1 disintegrin domain.