AID


ArtNr	18-783-313136
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Antibodies Western Blot Primary Antibodies
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-22F1A8
Similar products	18-783-313136
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Genway ID:	GWB-22F1A8
Specificity:	AID
Specificity:	AID
Immunogen:	A 14 amino acid peptide located near human AID carboxy-terminus.
Preparation:	Antisera to human AID (CT) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG pepared by affinity chromatography.
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 02% Sodium Azide (NaN3) Suggested
Dilution:	Suggested
Dilution:	Western Blotting - 2ug/ml
Function:	RNA-editing deaminase involved in somatic hypermutation gene conversion and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.
Catalytic Activity:	Cytidine + H2O = uridine + NH3. Cofactor: Zinc (By similarity).
Tissue Specificity:	Strongly expressed in lymph nodes and tonsils.
Disease:	Defects in AICDA are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]. HIGM2 is characterized by normal or elevated serum IgM levels with absence of IgG IgA and IgE resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR) the lack of Ig somatic hypermutations and lymph node hyperplasia caused by the presence of giant germinal centers.
Similarity:	Belongs to the cytidine and deoxycytidylate deaminase family. 1. Muramatsu. M. et al. (1999) Specific expression of activation-induced cytidine deaminase (AID). a novel member of the RNA-editing deaminase family in germinal center B cells*. 2. Muramatsu. M. et al. (2000) Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID). a potential RNA editing enzyme. 3. Yu. K. et al. (2005) Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops.

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