SOCS 1

SOCS 1 NCBI

SOCS 1

This product recognises Suppressor of cytokine signalling 1 (SOCS1) a 24kDa member of the Suppressor of cytokine signalling family. SOCS1 acts downstream of cytokine receptors and plays a role in the negative regulation of cytokine signalling. It acts mainly on the Janus kinase (JAK)/signal transducers and activators of transcription-3 (STAT3) pathway but also inhibits signalling by cytokines such as insulin and toll-like receptors. Furthermore SOCS1 is involved in ubiquitin-dependent protein degradation plays a role in T cell activation and in the regulation of IL-6 IL-4 IL-12 and IL-15. SOCS1 is expressed ubiquitously and at elevated levels in the spleen small intestine and peripheral blood leukocytes.

Phosphate buffered saline

Western Blot: This product detects a band of approximately 24kDa in human spleen cell lysates. Suggested

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs inhibits their kinase activity. In vitro also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.

Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases TEC KIT GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC CUL5 RBX1 and SOCS1 (By similarity). Interacts with TRIM8 (By similarity). Interacts with CUL2.

By a subset of cytokines including those belonging to the interferon interleukin and colony-stimulating factor families.

The SOCS box domain mediates the interaction with the Elongin BC complex an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity).

Contains 1 SOCS box domain. 1. Davey. G. et al. (2006) SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation. 2. Rakesh. K. et al. (2005) Controlling cytokine signaling by constitutive inhibitors.