ACE 2

ACE 2 NCBI

ACE 2

This product is specific for human Angiotensin-converting enzyme 2 (ACE2). ACE2 is a carboxypeptidase which is expressed in a range of tissues including heart kidney testis and the gastrointestinal system. ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1) although it has a distinct catalytic activity. ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7 which may counteract the effects of ACE by increasing vasodilatation. A recent discovery is that ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus functioning as a receptor for the SARS Spike protein.

Antisera to human ACE2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Activated by chloride and fluoride but not bromide. Inhibited by MLN-4760 cFP_Leu and EDTA but not by the ACE inhibitors linosipril captopril and enalaprilat. Biophysicochemical Properties:

Processed angiotensin-converting enzyme 2: Secreted.

Expressed in endothelial cells from small and large arteries and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells enterocytes of the small intestine Leydig cells and Sertoli cells (at protein level). Expressed in heart kidney testis and gastrointestinal system.

N-glycosylation on Asn-90 may limit SARS infectivity.