Cyclin E2 (C-term)

GWB-41F31E

A synthetic peptide corresponding to residues in C-terminus of human Cyclin E2 was used as immunogen. Predicted to cross-react with mouse and bovine based on sequence homology.

WB: 1:500IHC: 1:50ICC: 1:100-1:250FC: 1:20. Cyclin E2 is a member of the cyclin E family that can associate with and activate Cdk2. Expression of cyclin E2 is essential for the control of the cell cycle at the late G1 and early S phase and this protein may regulate distinct rate-limiting pathway(s) during this phase (1). Cyclin E2 specifically interacts with Cdk inhibitors of the CIP/KIP family and activates both Cdk2 and Cdk3. Expression of the viral E6 oncoprotein in normal human fibroblasts increases levels of cyclin E2 but not cyclin E1 while expression of the E7 oncoprotein upregulates both (2). Abnormally high levels of cyclin E expression have frequently been observed in human cancers (3). 1. Lauper N. et al. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. Oncogene 17: 26372. Zariwala M. et al. Cyclin E2 a novel human G1 cyclin and activating partner of CDK2 and CDK3 is induced by viral oncoproteins. Oncogene 17: 27873. Gudas J. M. et al. Cyclin E2 a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. Mol Cell Biol. 19: 6124. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487