ATP-citrate lyase (C-term)

GWB-7EDFBA

A synthetic peptide corresponding to residues in the C-term of human ATP citrate lyase was used as immunogen.

WB: 1:1 000-10 000FC: 1: 30IP: 1:50. ATP citrate lyase (ACL) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of four identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. One of these products acetyl-CoA serves several important biosynthetic pathways including lipogenesis and cholesterogenesis. In nervous tissue ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. NDPK has been found to phosphorylate ACL and insulin to increase phosphorylation of ACL (2). 1. King FW Fong S Griffin C et al ATP-citrate lyase PLoS One 4 (2009) e7283[Application: WB]1. Elshourbagy et al. Europ. J. Biochem. 204: 491-499 1992. 2. Benjamin W. B. and Singer I. (1974) Biochim. Biophys. Acta 251 28-423. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487