PAPP A [18A10]

ArtNr	20-272-190113
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Adenocarcinoma Western Blot ELISA Primary Antibodies By Organ Bone Cancer
Typ	Antibody
Applikationen	WB, ELISA
Clon	18A10
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-1F4866
Similar products	20-272-190113
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Genway ID:	GWB-1F4866
Clone:	18A10
Isotype:	IgG2a
Immunogen:	Purified human PAPPA antigen
Antigen Species:	Human
Target:	PAPP A
Purification Note:	Purified by chromatography on protein A. Purity tested by electrophoresis Storage
Preservative:	0. 1% Sodium Azide; Constituents: PBS. pH 7. 4
Application Note:	ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Detects a band of approximately 200 kDa under reducing conditions. (predicted
Molecular Weight:	195 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Myeloma: Sp2/0 Pregnancy-associated plasma protein A (PAPPA) is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.
Function:	Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5 resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Catalytic Activity:	Cleavage of the 135-Met-\|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4 and the 143-Ser-\|-Lys-144 bond in IGFBP-5. Cofactor: Binds 1 zinc ion per subunit (By similarity).
Enzyme Regulation:	Inhibited by complexation with the proform of PRG2.
Subunit:	Homodimer; disulfide-linked. In pregnancy serum predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.
Subcellular Location:	Secreted.
Tissue Specificity:	High levels in placenta and pregnancy serum. In placenta expressed in X cells in septa and anchoring villi and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney myometrium endometrium ovaries breast prostate bone marrow colon fibroblasts and osteoblasts. Developmental Stage: Present in serum and placenta during pregnancy; levels increase throughout pregnancy.
Induction:	By 8-bromoadenosine-3\' 5\' -phosphate.
Ptm:	There appear to be no free sulfhydryl groups.
Similarity:	Belongs to the peptidase M43B family [view classification].
Similarity:	Contains 5 Sushi (CCP/SCR) domains.

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