SAA [291]

GWB-93451C

IgG2bLight chain: kappa

Human

SAA

1 mg/ml Storage

For ELISA: Use at an assay dependent dilution. For WB: Use at a concentration of 0. 1 - 0. 5 µ g/ml. Detects a band of approximately 12 kDa (predicted

Secreted Myeloma: Sp2/0-Ag14 The serum amyloid A family comprises a number of differentially expressed apolipoproteins acute-phase SAA1 and SAA2 the former being the major component in plasma and constitutive SAAs. Although the liver is the primary site of synthesis of both SAA types extrahepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations; SAA rises earlier and more sharply than CRP. Recently a broader view of SAA expression and function has been emerging. Expression studies show production of SAA proteins in histologically normal atherosclerotic Alzheimer inflammatory and tumour tissues. SAA has been found to have binding sites for high density lipoproteins calcium laminin and heparin/heparin sulphate. Also adhesion motifs were identified and new functions affecting cell adhesion migration proliferation and aggregation were discovered. These findings emphasize the importance of SAA in various physiological and pathological processes including inflammation atherosclerosis thrombosis AA-amyloidosis rheumatoid arthritis and neoplasia. SAA has also a number of immunomodulatory roles it can induce chemotaxis and adhesion molecule expression has cytokine-like properties and can promote the upregulation of metalloproteinases. It enhances the binding of high density lipoprotein to macrophages and thus helps in the delivery of lipids to sites of injury for use in tissue repair it is thus thought to be an integral part of the disease process.

Secreted.

Upon cytokine stimulation.

Both SAA1 and SAA2 have a number of alleles. We use here the nomenclature of Ref. 6. The sequence shown is that of 1-alpha.

BOL is from a patient with Waldenstrom macroglobulinemia.

TH is from a patient with juvenile rheumatoid arthritis.

Belongs to the SAA family.