GPBB [7B9]

ArtNr	20-272-192148
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Neuroscience Metabolism Glucose Homeostasis Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Development Antibodies Western Blot ELISA Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	WB, ELISA
Clon	7B9
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-50CD96
Similar products	20-272-192148
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Genway ID:	GWB-50CD96
Clone:	7B9
Isotype:	IgG1
Immunogen:	Full length protein (Human).
Antigen Species:	Human
Specificity:	Specific to the BB isoenzyme.
Target:	GPBB
Localization:	Plasma membrane
Purification Note:	Purified by chromatography on protein A Sepharose. Purity is tested by electrophoresis. Storage
Preservative:	0. 1% Sodium Azide; Constituents: PBS
Application Note:	AP: Use at an assay dependent dilution. ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Can be paired for ELISA with 20-272-192146 Mouse monoclonal [6F1] to GPBB . Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Plasma membrane Myeloma: Sp2/0 GPBB - sensitive marker for the AMI diagnosis within 4 hours after the onset of chest pain. It has been also shown that GPBB increased in a considerable proportion of AMI patients within 2-3 hours from chest pain onset. GPBB increased early in patients with unstable angina. GPBB can be also a sensitive marker for the detection of peri-operative myocardial ischaemia and infraction in patients undergoing coronary artery bypass grafting.
Function:	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However all known phosphorylases share catalytic and structural properties.
Catalytic Activity:	(1 4-alpha-D-glucosyl)(n) + phosphate = (1 4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate. Cofactor: Pyridoxal phosphate.
Enzyme Regulation:	Activity of phosphorylase is controlled both by allosteric means (through the non-covalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates whereas ATP ADP and glucose-6-phosphate allosterically inhibit phosphorylase B.
Subunit:	Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Ptm:	Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.
Similarity:	Belongs to the glycogen phosphorylase family.

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Menge: 0.1 mg

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