XRCC1 [33-2-5]

ArtNr	20-272-192247
Hersteller	GENWAY
Menge	0.25 ml
Kategorie	Oncology Antibodies Immunohistochemistry Immunoprecipitation Western Blot Immunofluorescence Primary Antibodies By Organ Testicular & Prostate Cancer
Typ	Antibody
Applikationen	WB, IF, IP, IHC
Clon	33-2-5
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-42119B
Similar products	20-272-192247
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Genway ID:	GWB-42119B
Clone:	33-2-5
Isotype:	IgG2b
Immunogen:	Recombinant full length protein (Human).
Antigen Species:	Human
Specificity:	This antibody is specific for XRCC1 (85 kDa).
Positive Control:	Testis.
Target:	XRCC1
Localization:	Nuclear
Purification Note:	From mouse ascitic fluid Storage
Preservative:	Sodium Azide
Application Note:	IF: Use at an assay dependent dilution. IHC-P: Use at a dilution of 1/50 - 1/100. Perform enzymatic antigen retrieval before commencing with IHC staining protocol (10 mM citrate buffer pH 6. 0 ). IHC-Fr: Use at a dilution of 1/50 - 1/100. IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted
Molecular Weight:	85 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Nuclear X-ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNS ligase III through the C-terminal 96 amino acids and to DNA polymerase beta through the N-terminal half. In testis XRCC1 is expressed at high levels.
Function:	Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
Subunit:	Homodimer. Interacts with polynucleotide kinase (PNK) DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF.
Subcellular Location:	Nucleus. Note=Accumulates at sites of DNA damage.
Ptm:	Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
Ptm:	Sumoylated.
Polymorphism:	Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.
Similarity:	Contains 2 BRCT domains.

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