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IL2-R alpha [MEM-140]

ArtNr 20-272-192554
Hersteller GENWAY
Menge 0.1 mg
Kategorie
Typ Antibody
Applikationen IP
Clon MEM-140
Specific against other
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-B10608
Similar products 20-272-192554
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Genway ID:
GWB-B10608
Clone:
MEM-140
Isotype:
IgM
Immunogen:
PHA-activated peripheral blood leucocytes.
Target:
IL2-R alpha
Localization:
Cell Membrane
Concentration:
1 mg/ml
Purification Note:
Purified from ascites by thiophilic adsorption-affinity. chromatography. Storage
Buffer:
Phosphate buffered saline pH 7. 4 containing 15mM sodium azide
Application Note:
Not tested in applications other than those listed above. Optimal dilutions / concentrations should be determined by the end user. Cellular
Localization:
Cell Membrane The interleukin 2 receptor alpha (IL2RA) and beta (IL2RB) chains together with the common gamma chain (IL2RG) constitute the high affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low affinity receptor while homodimeric beta (IL2RB) chains produce a medium affinity receptor. Normally an integral membrane protein soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately spliced IL2RA mRNAs have been isolated but the significance of each is presently unknown.
Function:
Receptor for interleukin-2.
Subunit:
Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer an intermediate affinity monomer (beta chain) and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Disease:
Genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942].
Similarity:
Contains 2 Sushi (CCP/SCR) domains.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 0.1 mg
Lieferbar: In stock
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