HNRNP F [3H4]

3H4

Full length hnRNPF protein (Human).

HNRNP F

1 mg/ml

0. 1% Sodium Azide; Constituents: PBS

Nuclear Myeloma: Sp2/0 This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH.

Identified in the spliceosome C complex at least composed of AQR ASCC3L1 C19orf29 CDC40 CDC5L CRNKL1 DDX23 DDX41 DDX48 DDX5 DGCR14 DHX35 DHX38 DHX8 EFTUD2 FRG1 GPATC1 HNRPA1 HNRPA2B1 HNRPA3 HNRPC HNRNPF HNRPH1 HNRPK HNRPM HNRPR HNRPU KIAA1160 KIAA1604 LSM2 LSM3 MAGOH MORG1 PABPC1 PLRG1 PNN PPIE PPIL1 PPIL3 PPWD1 PRPF19 PRPF4B PRPF6 PRPF8 RALY RBM22 RBM8A RBMX SART1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SFRS1 SKIV2L2 SNRPA1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNW1 SRRM1 SRRM2 SYF2 SYNCRIP TFIP11 THOC4 U2AF1 WDR57 XAB2 and ZCCHC8. Interacts with TBP and TXNL4/DIM1.

Expressed ubiquitously.

Contains 3 RRM (RNA recognition motif) domains.