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CD152 [WKH203] (FITC)

CD152 [WKH203] (FITC)

ArtNr	20-272-193843
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Primary Antibodies By Organ Hepatic Cancer
Typ	Antibody
Clon	WKH203
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-717321
Similar products	20-272-193843
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Genway ID:	GWB-717321
Clone:	WKH203
Isotype:	IgG1
Immunogen:	Purified rCTLA-4hIg fusion protein.
Target:	CD152
Conjugation:	FITC
Concentration:	0. 1 mg/ml Storage
Buffer:	Phosphate-buffered saline containing BSA and 0. 02% sodium azide
Application Note:	For FACS: Use at an assay dependent dilution. Not tesetd in other applications. Optimal diluitons/concentrations should be determined by the researcher. Recognises rat cytotoxic-T-lymphocyte antigen-4 (CTLA-4) also known as CD152. CD152 is similar in structure to CD28 and also binds ligands CD80 and CD86. CD152 is expressed by activated T-lymphocytes. Studies suggest that CD152 is also expressed by regulatory T-lymphocytes.
Function:	Possibly involved in T-cell activation. Binds to B7-1 (CD80) and B7-2 (CD86).
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Widely expressed with highest levels in lymphoid tissues.
Disease:	Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin joints kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Disease:	Genetic variation in CTLA4 may be a cause of susceptibility to Graves disease (GRD) [MIM:275000]. GRD is an autoimmune disorder causing overactivity of the thyroid gland and hyperthyroidism.
Disease:	Genetic variation in CTLA4 is the cause of susceptibility to insulin-dependent diabetes mellitus type 12 (IDDM12) [MIM:601388].
Disease:	Genetic variation in CTLA4 is the cause of susceptibility to celiac disease type 3 (CELIAC3) [MIM:609755]. Celiac disease [MIM:212750] is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form celiac disease is characterized in children by malabsorption and failure to thrive.
Disease:	Genetic variations in CTLA4 are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection acute self-limited hepatitis or fulminant hepatitis requiring liver transplantation.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

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Menge: 0.1 mg

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