RP105 (CD180)

MHR73

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).

Cell membrane; Single-pass type I membrane protein.

Decreased expression of LY64 has been shown in systemic lupus erythematosus (SLE). The loss of LY64 is associated with B-cell activation and increased disease activity in SLE patients.

Contains 17 LRR (leucine-rich) repeats. [1] Miura Y. Miyake K. Yamashita Y. Shimazu R. Copeland N. G. Gilbert D. J. Jenkins N. A. Inazawa J. Abe T. and Kimoto M. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)[2] Miura Y. Miyake K. Shimazu R. Yamashita Y. Copeland N. G. Gilbert D. J. Jenkins N. A. Inazawa J. Abe T. and Masao K. Molecular cloning of a human RP105 homologue and chromosomal localizati on of the mouse and human RP105 genes[3] Miyake K. et al. Direct Submission[4] Miura Y. Miyake K. Yamashita Y. Shimazu R. Copeland N. G. Gilbert D. J. Jenkins N. A. Inazawa J. Abe T. Kimoto M. et al. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). [5] Zhang Z. Henzel W. J. Signal peptide prediction based on analysis of experimentally verified cleavage sites. [6] Miura Y. Shimazu R. Miyake K. Akashi S. Ogata H. Yamashita Y. Narisawa Y. Kimoto M. RP105 is associated with MD-1 and transmits an activation signal in human B cells.