Lamin (Mixed)

ArtNr	20-511-240482
Hersteller	GENWAY
Menge	1mg
Kategorie	Oncology Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	WB, IF, IHC
Clon	Mixed
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-4246F6
Similar products	20-511-240482
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Genway ID:	GWB-4246F6
Isotype:	IgG1
Clone:	MixedHost Animal: Mouse
Immunogen:	Nuclear pore complex-lamina fraction of Xenopus laevis (XLKE-A6 cells).
Specificity:	The monoclonal antibody cocktail recognizes the karyoskeleton. i. e. the intermediate filament proteins of the nucleus. Reacts with Lamin isotypes of Mr 60-75 kDa.
Type of Product:	Monoclonal Antibodies to Collagens and Extracellular Matrix Proteins
Concentration:	Not determinedPreservatives: NaN3
Buffer:	Not applicableApplications Notes : Immunohistochemistry (use undiluted). Immunofluorescence microscopy. Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to Lamin (Mixed). Monoclonal Antibody to Lamin Mixed Epitopes
Function:	Lamins are components of the nuclear lamina a fibrous layer on the nucleoplasmic side of the inner nuclear membrane which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Subunit:	Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA IB and TMPO-alpha RB1 and with emerin. Proteolytically processed isoform A interacts with NARF (By similarity). Interacts with SREBF1 SREBF2 and TMEM43.
Subcellular Location:	Nucleus.
Tissue Specificity:	Isoform C2 is specifically expressed in germ cells. This specific expression and unique structure suggests a role for this isoform in determining the organization of nuclear and chromosomal structures during spermatogenesis.
Ptm:	Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
Ptm:	Isoform C is phosphorylated on Ser-392 Ser-407 and Ser-409 at interphase.
Ptm:	The N-terminus is blocked.
Ptm:	The C-terminal 18 residues are removed by proteolytic cleavage in isoform A. Proteolytic cleavage requires prior farnesylation and absence of farnesylation blocks cleavage.
Miscellaneous:	The structural integrity of the lamina is strictly controlled by the cell cycle as seen by the disintegration and formation of the nuclear envelope in prophase and telophase respectively.
Similarity:	Belongs to the intermediate filament family.

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